Drug interactions
Esomeprazole + Ledipasvir-sofosbuvir
Severity: Moderate
Esomeprazole and Ledipasvir-sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esomeprazole suppresses gastric acid, and ledipasvir absorption falls as pH rises. This could reduce antiviral exposure and efficacy.
What this interaction means in plain words
Esomeprazole and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esomeprazole belongs to Gastrointestinal Tract; Ledipasvir-sofosbuvir belongs to Anti Virals.
Why it happens
Sustained acid suppression raises gastric pH and lowers ledipasvir solubility.
What to do
Use a PPI dose no higher than omeprazole 20 mg equivalent, taken together with ledipasvir/sofosbuvir under fasting conditions. Avoid higher doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Esomeprazole with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as moderate. Esomeprazole and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esomeprazole suppresses gastric acid, and ledipasvir absorption falls as pH rises. This could reduce antiviral exposure and efficacy.
How serious is the interaction between Esomeprazole and Ledipasvir-sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a PPI dose no higher than omeprazole 20 mg equivalent, taken together with ledipasvir/sofosbuvir under fasting conditions. Avoid higher doses.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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