Drug interactions
Esomeprazole + Pazopanib
Severity: Major
Esomeprazole and Pazopanib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib absorption depends on gastric acidity, and PPIs can lower its exposure and efficacy. Reduced tumor control is the concern.
What this interaction means in plain words
Esomeprazole and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Esomeprazole belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Raised gastric pH reduces the solubility and absorption of pazopanib.
What to do
Avoid concurrent use where possible. If acid suppression is essential, give pazopanib once daily without food in the evening, at the same time as the PPI, or use a short-acting antacid separated by several hours.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Esomeprazole with Pazopanib?
MediHelp rates the interaction as major. Esomeprazole and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib absorption depends on gastric acidity, and PPIs can lower its exposure and efficacy. Reduced tumor control is the concern.
How serious is the interaction between Esomeprazole and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If acid suppression is essential, give pazopanib once daily without food in the evening, at the same time as the PPI, or use a short-acting antacid separated by several hours.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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