Drug interactions
Estazolam + Lisdexamfetamine
Severity: Minor
Estazolam and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estazolam is a sedative benzodiazepine hypnotic and lisdexamfetamine is a stimulant. Opposing effects may make sedation and cognitive impairment hard to judge, and the stimulant can worsen insomnia that estazolam treats. The interaction is not well characterised.
What this interaction means in plain words
Estazolam and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects: GABA-A potentiation versus amphetamine-mediated catecholamine release.
What to do
Separate lisdexamfetamine to the morning to avoid counteracting the hypnotic. Monitor sleep quality and psychomotor function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Estazolam with Lisdexamfetamine?
MediHelp rates the interaction as minor. Estazolam and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estazolam is a sedative benzodiazepine hypnotic and lisdexamfetamine is a stimulant. Opposing effects may make sedation and cognitive impairment hard to judge, and the stimulant can worsen insomnia that estazolam treats. The interaction is not well characterised.
How serious is the interaction between Estazolam and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate lisdexamfetamine to the morning to avoid counteracting the hypnotic. Monitor sleep quality and psychomotor function.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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