Drug interactions
Estradiol + Imipramine
Severity: Minor
Estradiol and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may raise imipramine plasma concentrations and increase tricyclic adverse effects such as sedation, dry mouth and orthostatic hypotension. Some reports also suggest a reduced antidepressant response, so the net effect on an individual patient is unpredictable.
What this interaction means in plain words
Estradiol and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Imipramine belongs to Central Nervous System.
Why it happens
Estrogens may reduce hepatic clearance of tricyclics, but the mechanism is not firmly established.
What to do
Monitor for tricyclic adverse effects and antidepressant response when estrogen is started, stopped or changed. Consider a tricyclic plasma level or dose reduction if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Imipramine?
MediHelp rates the interaction as minor. Estradiol and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may raise imipramine plasma concentrations and increase tricyclic adverse effects such as sedation, dry mouth and orthostatic hypotension. Some reports also suggest a reduced antidepressant response, so the net effect on an individual patient is unpredictable.
How serious is the interaction between Estradiol and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and antidepressant response when estrogen is started, stopped or changed. Consider a tricyclic plasma level or dose reduction if toxicity appears.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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