Drug interactions
Estradiol + Ivosidenib
Severity: Moderate
Estradiol and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower estradiol concentrations. Reduced exposure may cause loss of symptom control or breakthrough bleeding, and may reduce efficacy of estrogen-containing contraception.
What this interaction means in plain words
Estradiol and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estradiol belongs to Endocrine; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing estradiol clearance.
What to do
Monitor for loss of estrogenic effect and adjust the estradiol dose as needed. Advise additional non-hormonal contraception where contraception is relied upon.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Estradiol with Ivosidenib?
MediHelp rates the interaction as moderate. Estradiol and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower estradiol concentrations. Reduced exposure may cause loss of symptom control or breakthrough bleeding, and may reduce efficacy of estrogen-containing contraception.
How serious is the interaction between Estradiol and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of estrogenic effect and adjust the estradiol dose as needed. Advise additional non-hormonal contraception where contraception is relied upon.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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