Drug interactions
Estradiol + Mavacamten
Severity: Moderate
Estradiol and Mavacamten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten may induce CYP3A and lower exposure to progestins in combined hormonal contraceptives, risking contraceptive failure. Estradiol alone as menopausal therapy is less concerning, but the concern applies to contraceptive estrogen-progestin products.
What this interaction means in plain words
Estradiol and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estradiol belongs to Endocrine; Mavacamten belongs to Cardiovascular.
Why it happens
Mavacamten induction of CYP3A4 and related enzymes may increase hormone metabolism.
What to do
In patients relying on hormonal contraception, add a nonhormonal method or use an ethinyl estradiol/norethindrone product as labeled. Monitor for breakthrough bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Mavacamten?
MediHelp rates the interaction as moderate. Estradiol and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten may induce CYP3A and lower exposure to progestins in combined hormonal contraceptives, risking contraceptive failure. Estradiol alone as menopausal therapy is less concerning, but the concern applies to contraceptive estrogen-progestin products.
How serious is the interaction between Estradiol and Mavacamten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients relying on hormonal contraception, add a nonhormonal method or use an ethinyl estradiol/norethindrone product as labeled. Monitor for breakthrough bleeding.
What other medicines interact with Mavacamten?
MediHelp also lists interactions of Mavacamten with, for example, Apalutamide, Carbamazepine, Clarithromycin. The full list is on the Mavacamten page.
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