Drug interactions
Estradiol + Miconazole
Severity: Minor
Estradiol and Miconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estradiol is partly metabolized by CYP3A4, and CYP3A4 inhibitors can modestly increase estrogen levels. Systemic miconazole exposure from vaginal use is small. Any change in estrogenic effect is likely minor.
What this interaction means in plain words
Estradiol and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP3A4, slightly decreasing estradiol metabolism.
What to do
No action is generally needed. Watch for estrogen excess effects such as breast tenderness or bleeding if miconazole is used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Miconazole
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Miconazole?
MediHelp rates the interaction as minor. Estradiol and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estradiol is partly metabolized by CYP3A4, and CYP3A4 inhibitors can modestly increase estrogen levels. Systemic miconazole exposure from vaginal use is small. Any change in estrogenic effect is likely minor.
How serious is the interaction between Estradiol and Miconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed. Watch for estrogen excess effects such as breast tenderness or bleeding if miconazole is used long term.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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