Drug interactions
Estradiol + Nelfinavir
Severity: Moderate
Estradiol and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir has been reported to lower ethinylestradiol levels rather than raise them, so the effect on estradiol is uncertain. Efficacy or tolerability of estradiol may change.
What this interaction means in plain words
Estradiol and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estradiol belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Mixed CYP3A4 inhibition and induction of other pathways (possibly glucuronidation) alters estradiol clearance unpredictably.
What to do
Monitor symptom control and estrogenic adverse effects and titrate the estradiol dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Estradiol with Nelfinavir?
MediHelp rates the interaction as moderate. Estradiol and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir has been reported to lower ethinylestradiol levels rather than raise them, so the effect on estradiol is uncertain. Efficacy or tolerability of estradiol may change.
How serious is the interaction between Estradiol and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and estrogenic adverse effects and titrate the estradiol dose accordingly.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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