Drug interactions
Estradiol + Nifedipine
Severity: Minor
Estradiol and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine may slightly alter estradiol exposure through effects on metabolism or transport, but no clinically important effect has been established. Estrogens can raise blood pressure in some patients, which could modestly counter antihypertensive therapy.
What this interaction means in plain words
Estradiol and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Nifedipine belongs to Cardiovascular.
Why it happens
Possible weak effects of nifedipine on CYP3A4 and P-glycoprotein handling of estradiol; not clinically established.
What to do
No dose change is needed; monitor blood pressure and estrogen-related effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Nifedipine?
MediHelp rates the interaction as minor. Estradiol and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine may slightly alter estradiol exposure through effects on metabolism or transport, but no clinically important effect has been established. Estrogens can raise blood pressure in some patients, which could modestly counter antihypertensive therapy.
How serious is the interaction between Estradiol and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor blood pressure and estrogen-related effects.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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