Drug interactions
Estradiol + Ropinirole
Severity: Minor
Estradiol and Ropinirole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens have been reported to reduce ropinirole clearance, leading to higher ropinirole concentrations in women on hormone therapy. This may increase dopaminergic adverse effects such as nausea, dizziness, somnolence and orthostatic hypotension.
What this interaction means in plain words
Estradiol and Ropinirole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Ropinirole belongs to Central Nervous System.
Why it happens
Reduced ropinirole clearance by estrogens, probably involving CYP1A2, though not fully established.
What to do
Titrate ropinirole to clinical response when estrogen therapy is started or stopped. Adjust the ropinirole dose if adverse effects appear or efficacy changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Estradiol and Ropinirole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Ropinirole?
MediHelp rates the interaction as minor. Estradiol and Ropinirole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens have been reported to reduce ropinirole clearance, leading to higher ropinirole concentrations in women on hormone therapy. This may increase dopaminergic adverse effects such as nausea, dizziness, somnolence and orthostatic hypotension.
How serious is the interaction between Estradiol and Ropinirole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ropinirole to clinical response when estrogen therapy is started or stopped. Adjust the ropinirole dose if adverse effects appear or efficacy changes.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
