Drug interactions
Estradiol + Somapacitan
Severity: Moderate
Estradiol and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral estrogens reduce hepatic IGF-1 production in response to growth hormone, so patients on oral estradiol may respond less to somapacitan. They may need higher somapacitan doses than patients not on oral estrogen.
What this interaction means in plain words
Estradiol and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estradiol belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Oral estrogen attenuates hepatic growth hormone signaling, reducing the IGF-1 response.
What to do
Titrate somapacitan to serum IGF-1 and clinical response, and reassess the dose if oral estrogen is started or stopped. Consider transdermal estradiol, which has less effect on IGF-1.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Estradiol with Somapacitan?
MediHelp rates the interaction as moderate. Estradiol and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral estrogens reduce hepatic IGF-1 production in response to growth hormone, so patients on oral estradiol may respond less to somapacitan. They may need higher somapacitan doses than patients not on oral estrogen.
How serious is the interaction between Estradiol and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate somapacitan to serum IGF-1 and clinical response, and reassess the dose if oral estrogen is started or stopped. Consider transdermal estradiol, which has less effect on IGF-1.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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