Drug interactions
Estradiol + Tolvaptan
Severity: Minor
Estradiol and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein and might slightly increase estradiol exposure. Clinical consequences are unlikely.
What this interaction means in plain words
Estradiol and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Tolvaptan belongs to Endocrine.
Why it happens
P-glycoprotein inhibition by tolvaptan may reduce estradiol efflux.
What to do
No action is required beyond awareness of estrogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Estradiol with Tolvaptan?
MediHelp rates the interaction as minor. Estradiol and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-glycoprotein and might slightly increase estradiol exposure. Clinical consequences are unlikely.
How serious is the interaction between Estradiol and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is required beyond awareness of estrogenic adverse effects.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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