Drug interactions
Estradiol vaginal + Posaconazole
Severity: Minor
Estradiol vaginal and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may modestly raise systemic estradiol exposure by inhibiting CYP3A4. Systemic absorption from vaginal preparations is low, so clinical impact is usually small.
What this interaction means in plain words
Estradiol vaginal and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Posaconazole inhibits CYP3A4-mediated estradiol metabolism.
What to do
Monitor for estrogenic effects such as breast tenderness or unexpected bleeding. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Estradiol vaginal with Posaconazole?
MediHelp rates the interaction as minor. Estradiol vaginal and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may modestly raise systemic estradiol exposure by inhibiting CYP3A4. Systemic absorption from vaginal preparations is low, so clinical impact is usually small.
How serious is the interaction between Estradiol vaginal and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic effects such as breast tenderness or unexpected bleeding. No routine dose change is needed.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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