Drug interactions
Estrogens esterified + Posaconazole
Severity: Minor
Estrogens esterified and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase esterified estrogen exposure through CYP3A4 inhibition. This could intensify estrogenic effects such as breast tenderness, fluid retention and abnormal uterine bleeding.
What this interaction means in plain words
Estrogens esterified and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Posaconazole inhibits CYP3A4-mediated estrogen metabolism.
What to do
Monitor for estrogenic adverse effects and reduce the estrogen dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Estrogens esterified with Posaconazole?
MediHelp rates the interaction as minor. Estrogens esterified and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may increase esterified estrogen exposure through CYP3A4 inhibition. This could intensify estrogenic effects such as breast tenderness, fluid retention and abnormal uterine bleeding.
How serious is the interaction between Estrogens esterified and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects and reduce the estrogen dose if needed.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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