Drug interactions
Eszopiclone + Iloperidone
Severity: Moderate
Eszopiclone and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak-to-moderate CYP3A4 inhibitor and can modestly raise eszopiclone exposure. This may increase sedation and next-day impairment. It also adds to sedation through its own central nervous system effects.
What this interaction means in plain words
Eszopiclone and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated eszopiclone metabolism combined with additive sedative effects.
What to do
Start eszopiclone at the lowest dose (1 mg) and titrate cautiously. Monitor for daytime sedation and psychomotor impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Eszopiclone with Iloperidone?
MediHelp rates the interaction as moderate. Eszopiclone and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a weak-to-moderate CYP3A4 inhibitor and can modestly raise eszopiclone exposure. This may increase sedation and next-day impairment. It also adds to sedation through its own central nervous system effects.
How serious is the interaction between Eszopiclone and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start eszopiclone at the lowest dose (1 mg) and titrate cautiously. Monitor for daytime sedation and psychomotor impairment.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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