Drug interactions
Eszopiclone + Letermovir
Severity: Moderate
Eszopiclone and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 and may moderately raise eszopiclone exposure, increasing sedation and impairment.
What this interaction means in plain words
Eszopiclone and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Letermovir belongs to Anti Virals.
Why it happens
Moderate CYP3A4 inhibition by letermovir reduces eszopiclone clearance.
What to do
Start eszopiclone at 1 mg and monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Eszopiclone with Letermovir?
MediHelp rates the interaction as moderate. Eszopiclone and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A4 and may moderately raise eszopiclone exposure, increasing sedation and impairment.
How serious is the interaction between Eszopiclone and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start eszopiclone at 1 mg and monitor for excessive sedation.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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