Drug interactions
Eszopiclone + Ribociclib
Severity: Moderate
Eszopiclone and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may raise eszopiclone exposure, since CYP3A4 is a major route of eszopiclone metabolism. Higher levels could cause more sedation and next-day impairment.
What this interaction means in plain words
Eszopiclone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing the metabolic clearance of eszopiclone.
What to do
Start with a low eszopiclone dose and do not exceed the labeled maximum for use with CYP3A4 inhibitors. Monitor for excess sedation and psychomotor impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Eszopiclone with Ribociclib?
MediHelp rates the interaction as moderate. Eszopiclone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and may raise eszopiclone exposure, since CYP3A4 is a major route of eszopiclone metabolism. Higher levels could cause more sedation and next-day impairment.
How serious is the interaction between Eszopiclone and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low eszopiclone dose and do not exceed the labeled maximum for use with CYP3A4 inhibitors. Monitor for excess sedation and psychomotor impairment.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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