Drug interactions
Eszopiclone + Selinexor
Severity: Moderate
Eszopiclone and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and fatigue, which may be worsened by sedative-hypnotics like eszopiclone. This raises the risk of falls and cognitive impairment.
What this interaction means in plain words
Eszopiclone and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive CNS adverse effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation, and counsel on fall and driving risk. Reduce or stop eszopiclone if neurologic effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Eszopiclone with Selinexor?
MediHelp rates the interaction as moderate. Eszopiclone and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and fatigue, which may be worsened by sedative-hypnotics like eszopiclone. This raises the risk of falls and cognitive impairment.
How serious is the interaction between Eszopiclone and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation, and counsel on fall and driving risk. Reduce or stop eszopiclone if neurologic effects emerge.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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