Drug interactions
Eszopiclone + Tipranavir
Severity: Moderate
Eszopiclone and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, produces net CYP3A4 inhibition and may raise eszopiclone concentrations. This can increase sedation and impairment.
What this interaction means in plain words
Eszopiclone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by ritonavir-boosted tipranavir reduces eszopiclone clearance.
What to do
Start eszopiclone at 1 mg and keep to 2 mg or less nightly. Monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Eszopiclone with Tipranavir?
MediHelp rates the interaction as moderate. Eszopiclone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, produces net CYP3A4 inhibition and may raise eszopiclone concentrations. This can increase sedation and impairment.
How serious is the interaction between Eszopiclone and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start eszopiclone at 1 mg and keep to 2 mg or less nightly. Monitor for oversedation.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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