Drug interactions
Eszopiclone + Voriconazole
Severity: Moderate
Eszopiclone and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and increases eszopiclone exposure, which can cause greater sedation, next-day impairment and complex sleep behaviours.
What this interaction means in plain words
Eszopiclone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces eszopiclone clearance.
What to do
Start eszopiclone at 1 mg and do not exceed 2 mg; warn the patient about daytime drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Eszopiclone
Frequently asked questions
Can I take Eszopiclone with Voriconazole?
MediHelp rates the interaction as moderate. Eszopiclone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4 and increases eszopiclone exposure, which can cause greater sedation, next-day impairment and complex sleep behaviours.
How serious is the interaction between Eszopiclone and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start eszopiclone at 1 mg and do not exceed 2 mg; warn the patient about daytime drowsiness.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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