Drug interactions
Etanercept + Etrasimod
Severity: Major
Etanercept and Etrasimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod is a sphingosine 1-phosphate receptor modulator that lowers circulating lymphocytes, and its use with immunosuppressants has not been well studied. Adding etanercept may produce additive immune suppression and a higher risk of infection.
What this interaction means in plain words
Etanercept and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etanercept belongs to Musculoskeletal; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from lymphocyte sequestration by etrasimod and TNF blockade by etanercept.
What to do
Avoid combined use where possible, allowing for the lingering effect of etrasimod after discontinuation. If used together, monitor lymphocyte counts and signs of infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Etanercept
- Bcg vaccine live + Etanercept Contraindicated
- Etanercept + Golimumab Contraindicated
- Etanercept + Measles mumps and rubella vaccine Contraindicated
- Etanercept + Measles mumps and rubella vaccine live Contraindicated
- Etanercept + Measles mumps rubella and varicella vaccine live Contraindicated
- Etanercept + Measles vaccine Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etanercept with Etrasimod?
MediHelp rates the interaction as major. Etanercept and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod is a sphingosine 1-phosphate receptor modulator that lowers circulating lymphocytes, and its use with immunosuppressants has not been well studied. Adding etanercept may produce additive immune suppression and a higher risk of infection.
How serious is the interaction between Etanercept and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible, allowing for the lingering effect of etrasimod after discontinuation. If used together, monitor lymphocyte counts and signs of infection.
What other medicines interact with Etanercept?
MediHelp also lists interactions of Etanercept with, for example, Bcg vaccine live, Golimumab, Measles mumps and rubella vaccine. The full list is on the Etanercept page.
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