Drug interactions
Etanercept + Ifosfamide
Severity: Moderate
Etanercept and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide causes myelosuppression and etanercept impairs host defence against infection, so together infection risk may rise. Febrile neutropenia may be more severe.
What this interaction means in plain words
Etanercept and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etanercept belongs to Musculoskeletal; Ifosfamide belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression.
What to do
Monitor blood counts and watch for signs of infection. Consider withholding etanercept during chemotherapy cycles with significant neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Etanercept and Ifosfamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Etanercept
- Bcg vaccine live + Etanercept Contraindicated
- Etanercept + Golimumab Contraindicated
- Etanercept + Measles mumps and rubella vaccine Contraindicated
- Etanercept + Measles mumps and rubella vaccine live Contraindicated
- Etanercept + Measles mumps rubella and varicella vaccine live Contraindicated
- Etanercept + Measles vaccine Contraindicated
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Etanercept with Ifosfamide?
MediHelp rates the interaction as moderate. Etanercept and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide causes myelosuppression and etanercept impairs host defence against infection, so together infection risk may rise. Febrile neutropenia may be more severe.
How serious is the interaction between Etanercept and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for signs of infection. Consider withholding etanercept during chemotherapy cycles with significant neutropenia.
What other medicines interact with Etanercept?
MediHelp also lists interactions of Etanercept with, for example, Bcg vaccine live, Golimumab, Measles mumps and rubella vaccine. The full list is on the Etanercept page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
