Drug interactions
Etanercept + Trastuzumab
Severity: Moderate
Etanercept and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etanercept blocks TNF and raises susceptibility to serious infections, while trastuzumab can add to neutropenia when given with myelosuppressive chemotherapy. Taken together in an oncology patient, the overall infection risk may be higher than with either drug alone.
What this interaction means in plain words
Etanercept and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etanercept belongs to Musculoskeletal; Trastuzumab belongs to Oncology.
Why it happens
Additive effects on immune defense: TNF blockade by etanercept plus potential neutropenia associated with trastuzumab-chemotherapy regimens.
What to do
Monitor for signs of infection and check neutrophil counts during chemotherapy-containing regimens. Withhold etanercept and treat promptly if a serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etanercept
- Bcg vaccine live + Etanercept Contraindicated
- Etanercept + Golimumab Contraindicated
- Etanercept + Measles mumps and rubella vaccine Contraindicated
- Etanercept + Measles mumps and rubella vaccine live Contraindicated
- Etanercept + Measles mumps rubella and varicella vaccine live Contraindicated
- Etanercept + Measles vaccine Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Etanercept with Trastuzumab?
MediHelp rates the interaction as moderate. Etanercept and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etanercept blocks TNF and raises susceptibility to serious infections, while trastuzumab can add to neutropenia when given with myelosuppressive chemotherapy. Taken together in an oncology patient, the overall infection risk may be higher than with either drug alone.
How serious is the interaction between Etanercept and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check neutrophil counts during chemotherapy-containing regimens. Withhold etanercept and treat promptly if a serious infection develops.
What other medicines interact with Etanercept?
MediHelp also lists interactions of Etanercept with, for example, Bcg vaccine live, Golimumab, Measles mumps and rubella vaccine. The full list is on the Etanercept page.
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