Drug interactions
Ethacrynic acid + Fluoxetine
Severity: Moderate
Ethacrynic acid and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics cause sodium loss and SSRIs can cause SIADH, so combining them may increase the risk of hyponatremia, especially in older adults.
What this interaction means in plain words
Ethacrynic acid and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive effects on sodium balance: diuretic natriuresis plus SSRI-associated SIADH.
What to do
Check serum sodium at baseline and after starting or changing doses. Watch for confusion, headache, nausea and falls, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Fluoxetine?
MediHelp rates the interaction as moderate. Ethacrynic acid and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics cause sodium loss and SSRIs can cause SIADH, so combining them may increase the risk of hyponatremia, especially in older adults.
How serious is the interaction between Ethacrynic acid and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and after starting or changing doses. Watch for confusion, headache, nausea and falls, particularly in older patients.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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