Drug interactions
Ethacrynic acid + Fluticasone-vilanterol
Severity: Moderate
Ethacrynic acid and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both vilanterol and loop diuretics such as ethacrynic acid can lower serum potassium. Together they may cause significant hypokalemia and ECG changes, particularly in patients with heart disease.
What this interaction means in plain words
Ethacrynic acid and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive hypokalemia from beta-2 agonist intracellular potassium shift and loop diuretic renal potassium loss.
What to do
Monitor serum potassium and magnesium periodically and replace as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Ethacrynic acid and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both vilanterol and loop diuretics such as ethacrynic acid can lower serum potassium. Together they may cause significant hypokalemia and ECG changes, particularly in patients with heart disease.
How serious is the interaction between Ethacrynic acid and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically and replace as needed.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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