Drug interactions
Ethacrynic acid + Fosinopril-hydrochlorothiazide
Severity: Moderate
Ethacrynic acid and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic that adds to thiazide-induced fluid and electrolyte loss. With an ACE inhibitor this can cause hypotension, hypokalemia, hyponatremia and acute renal insufficiency, especially at treatment start.
What this interaction means in plain words
Ethacrynic acid and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Sequential nephron blockade with additive volume depletion and potassium loss, plus ACE inhibitor reduction of glomerular filtration pressure.
What to do
Monitor blood pressure, serum electrolytes and creatinine when starting or increasing doses, and consider reducing diuretic doses if hypotension or volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Ethacrynic acid and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a potent loop diuretic that adds to thiazide-induced fluid and electrolyte loss. With an ACE inhibitor this can cause hypotension, hypokalemia, hyponatremia and acute renal insufficiency, especially at treatment start.
How serious is the interaction between Ethacrynic acid and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum electrolytes and creatinine when starting or increasing doses, and consider reducing diuretic doses if hypotension or volume depletion occurs.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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