Drug interactions
Ethacrynic acid + Indomethacin
Severity: Moderate
Ethacrynic acid and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can blunt the natriuretic and diuretic response to loop diuretics such as ethacrynic acid, and combined use increases the risk of renal impairment, especially in volume-depleted patients. Ethacrynic acid also carries ototoxicity risk, which is relevant in renal dysfunction.
What this interaction means in plain words
Ethacrynic acid and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, opposing loop diuretic action.
What to do
Monitor diuretic response, weight, blood pressure, and renal function and electrolytes. Increase the diuretic dose if needed or avoid NSAIDs in heart failure or renal disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Indomethacin?
MediHelp rates the interaction as moderate. Ethacrynic acid and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can blunt the natriuretic and diuretic response to loop diuretics such as ethacrynic acid, and combined use increases the risk of renal impairment, especially in volume-depleted patients. Ethacrynic acid also carries ototoxicity risk, which is relevant in renal dysfunction.
How serious is the interaction between Ethacrynic acid and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, weight, blood pressure, and renal function and electrolytes. Increase the diuretic dose if needed or avoid NSAIDs in heart failure or renal disease.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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