Drug interactions
Ethacrynic acid + Ipratropium-salbutamol
Severity: Moderate
Ethacrynic acid and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a loop diuretic that causes potassium loss, and salbutamol shifts potassium into cells. Together they can cause clinically significant hypokalemia, raising the risk of arrhythmia. The risk is higher with nebulized or high-dose salbutamol.
What this interaction means in plain words
Ethacrynic acid and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive hypokalemia from renal potassium wasting and beta-2-mediated cellular potassium uptake.
What to do
Monitor serum potassium and magnesium, and supplement as needed, particularly when salbutamol is used frequently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Ethacrynic acid and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a loop diuretic that causes potassium loss, and salbutamol shifts potassium into cells. Together they can cause clinically significant hypokalemia, raising the risk of arrhythmia. The risk is higher with nebulized or high-dose salbutamol.
How serious is the interaction between Ethacrynic acid and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, and supplement as needed, particularly when salbutamol is used frequently.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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