Drug interactions
Ethacrynic acid + Irbesartan
Severity: Moderate
Ethacrynic acid and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic that can cause volume depletion and add to irbesartan's blood pressure and renal effects. Potassium loss from the diuretic is partly offset by the ARB.
What this interaction means in plain words
Ethacrynic acid and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Irbesartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effect through diuresis and angiotensin receptor blockade, with opposing potassium effects.
What to do
Monitor blood pressure, volume status, creatinine and electrolytes when starting or adjusting either drug. Reduce the diuretic dose if hypotension or renal decline occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Irbesartan?
MediHelp rates the interaction as moderate. Ethacrynic acid and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a potent loop diuretic that can cause volume depletion and add to irbesartan's blood pressure and renal effects. Potassium loss from the diuretic is partly offset by the ARB.
How serious is the interaction between Ethacrynic acid and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status, creatinine and electrolytes when starting or adjusting either drug. Reduce the diuretic dose if hypotension or renal decline occurs.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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