Drug interactions
Ethacrynic acid + Magnesium
Severity: Moderate
Ethacrynic acid and Magnesium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid, a loop diuretic, increases urinary magnesium excretion and can cause hypomagnesemia with continued use. Low magnesium may worsen hypokalemia and arrhythmia risk.
What this interaction means in plain words
Ethacrynic acid and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Magnesium belongs to Gastrointestinal Tract.
Why it happens
Loop diuretics inhibit thick ascending limb reabsorption, reducing paracellular magnesium reabsorption.
What to do
Monitor serum magnesium and potassium during therapy. Replace magnesium when deficient.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethacrynic acid and Magnesium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Magnesium?
MediHelp rates the interaction as moderate. Ethacrynic acid and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid, a loop diuretic, increases urinary magnesium excretion and can cause hypomagnesemia with continued use. Low magnesium may worsen hypokalemia and arrhythmia risk.
How serious is the interaction between Ethacrynic acid and Magnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium during therapy. Replace magnesium when deficient.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
