Drug interactions
Ethacrynic acid + Milnacipran
Severity: Moderate
Ethacrynic acid and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics can cause hyponatremia, and SNRIs such as milnacipran can cause SIADH-related hyponatremia. Together the risk of low sodium may rise, especially in older adults.
What this interaction means in plain words
Ethacrynic acid and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Milnacipran belongs to Central Nervous System.
Why it happens
Additive hyponatremia from diuretic-induced sodium loss and SNRI-associated SIADH.
What to do
Check serum sodium at baseline and after starting or changing doses, especially in older patients. Report confusion, headache or nausea promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Milnacipran?
MediHelp rates the interaction as moderate. Ethacrynic acid and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics can cause hyponatremia, and SNRIs such as milnacipran can cause SIADH-related hyponatremia. Together the risk of low sodium may rise, especially in older adults.
How serious is the interaction between Ethacrynic acid and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and after starting or changing doses, especially in older patients. Report confusion, headache or nausea promptly.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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