Drug interactions
Ethacrynic acid + Nadolol
Severity: Moderate
Ethacrynic acid and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so additive hypotension can occur. Ethacrynic acid causes potassium and volume loss, which can contribute to hypotension and arrhythmia risk.
What this interaction means in plain words
Ethacrynic acid and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effect, with loop diuretic-induced volume and electrolyte depletion.
What to do
Monitor blood pressure, volume status and serum potassium and magnesium. Lower doses or replace electrolytes as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Nadolol?
MediHelp rates the interaction as moderate. Ethacrynic acid and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so additive hypotension can occur. Ethacrynic acid causes potassium and volume loss, which can contribute to hypotension and arrhythmia risk.
How serious is the interaction between Ethacrynic acid and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status and serum potassium and magnesium. Lower doses or replace electrolytes as needed.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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