Drug interactions
Ethacrynic acid + Oxaprozin
Severity: Moderate
Ethacrynic acid and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and natriuretic response to loop diuretics and increase the risk of acute kidney injury. Ethacrynic acid may also add to gastrointestinal bleeding risk and ototoxicity risk is unaffected but renal risk is higher.
What this interaction means in plain words
Ethacrynic acid and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
Oxaprozin inhibits renal prostaglandin synthesis, causing sodium retention and reducing renal blood flow, which opposes loop diuretic effect.
What to do
Monitor diuretic response, weight, blood pressure, renal function and electrolytes. Use the lowest NSAID dose for the shortest time, with extra care in heart failure or cirrhosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Oxaprozin?
MediHelp rates the interaction as moderate. Ethacrynic acid and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and natriuretic response to loop diuretics and increase the risk of acute kidney injury. Ethacrynic acid may also add to gastrointestinal bleeding risk and ototoxicity risk is unaffected but renal risk is higher.
How serious is the interaction between Ethacrynic acid and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, weight, blood pressure, renal function and electrolytes. Use the lowest NSAID dose for the shortest time, with extra care in heart failure or cirrhosis.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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