Drug interactions
Ethacrynic acid + Sulindac
Severity: Moderate
Ethacrynic acid and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and natriuretic response to loop diuretics such as ethacrynic acid. Both agents can also affect renal function, and the combination may increase the risk of acute kidney injury, particularly in volume-depleted patients.
What this interaction means in plain words
Ethacrynic acid and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, antagonizing loop diuretic effect.
What to do
Monitor blood pressure, fluid status, weight and serum creatinine. Increase the diuretic dose if response is diminished, or avoid the NSAID in heart failure or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Sulindac?
MediHelp rates the interaction as moderate. Ethacrynic acid and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and natriuretic response to loop diuretics such as ethacrynic acid. Both agents can also affect renal function, and the combination may increase the risk of acute kidney injury, particularly in volume-depleted patients.
How serious is the interaction between Ethacrynic acid and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, weight and serum creatinine. Increase the diuretic dose if response is diminished, or avoid the NSAID in heart failure or renal impairment.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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