Drug interactions
Ethacrynic acid + Warfarin
Severity: Moderate
Ethacrynic acid and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid may displace warfarin from plasma protein binding and has been reported to increase anticoagulant effect. Clinical significance is variable, but INR may rise with bleeding risk.
What this interaction means in plain words
Ethacrynic acid and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
Probable displacement of warfarin from albumin binding sites; not well characterised.
What to do
Monitor INR when starting or stopping ethacrynic acid and adjust the warfarin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Warfarin?
MediHelp rates the interaction as moderate. Ethacrynic acid and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid may displace warfarin from plasma protein binding and has been reported to increase anticoagulant effect. Clinical significance is variable, but INR may rise with bleeding risk.
How serious is the interaction between Ethacrynic acid and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR when starting or stopping ethacrynic acid and adjust the warfarin dose if needed.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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