Drug interactions
Ethanol + Lisdexamfetamine
Severity: Moderate
Ethanol and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alcohol is a CNS depressant and lisdexamfetamine is a stimulant. The stimulant may reduce perceived intoxication without reducing impairment, leading to greater alcohol intake. Both can also affect the cardiovascular system and judgement.
What this interaction means in plain words
Ethanol and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS pharmacodynamic effects that mask subjective intoxication, with additive cardiovascular strain.
What to do
Advise patients to avoid alcohol while taking lisdexamfetamine. Counsel that alertness does not indicate that driving is safe.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Ethanol with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Ethanol and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol is a CNS depressant and lisdexamfetamine is a stimulant. The stimulant may reduce perceived intoxication without reducing impairment, leading to greater alcohol intake. Both can also affect the cardiovascular system and judgement.
How serious is the interaction between Ethanol and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid alcohol while taking lisdexamfetamine. Counsel that alertness does not indicate that driving is safe.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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