Drug interactions
Ethanol + Metoclopramide
Severity: Moderate
Ethanol and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alcohol may add to the sedative effects of metoclopramide, and metoclopramide's faster gastric emptying can increase the rate of alcohol absorption. This can impair alertness and psychomotor performance.
What this interaction means in plain words
Ethanol and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and accelerated gastric emptying increasing alcohol absorption.
What to do
Advise patients to avoid alcohol during metoclopramide therapy and not to drive or operate machinery if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Ethanol with Metoclopramide?
MediHelp rates the interaction as moderate. Ethanol and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol may add to the sedative effects of metoclopramide, and metoclopramide's faster gastric emptying can increase the rate of alcohol absorption. This can impair alertness and psychomotor performance.
How serious is the interaction between Ethanol and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid alcohol during metoclopramide therapy and not to drive or operate machinery if drowsy.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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