Drug interactions
Ether + Lisdexamfetamine
Severity: Major
Ether and Lisdexamfetamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ether sensitizes the myocardium to catecholamines. With amphetamine from lisdexamfetamine, ventricular arrhythmias and hypertension may occur during anesthesia.
What this interaction means in plain words
Ether and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Anesthetic sensitization of the myocardium to catecholamines combined with amphetamine-induced catecholamine release.
What to do
Withhold the stimulant before planned anesthesia per local protocol and monitor ECG and blood pressure throughout.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Ether with Lisdexamfetamine?
MediHelp rates the interaction as major. Ether and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ether sensitizes the myocardium to catecholamines. With amphetamine from lisdexamfetamine, ventricular arrhythmias and hypertension may occur during anesthesia.
How serious is the interaction between Ether and Lisdexamfetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold the stimulant before planned anesthesia per local protocol and monitor ECG and blood pressure throughout.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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