Drug interactions
Ethinyl estradiol-drospirenone + Lapatinib
Severity: Minor
Ethinyl estradiol-drospirenone and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP3A4 inhibitor and might slightly raise lapatinib exposure. Clinically important effects are not well documented, and estrogen-containing contraceptives are generally unsuitable in patients with hormone-sensitive breast cancer.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Lapatinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by ethinyl estradiol may reduce lapatinib metabolism.
What to do
No dose change needed; monitor for lapatinib adverse effects such as diarrhea, rash and QT changes. Use a non-hormonal contraceptive method during lapatinib therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Lapatinib?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol is a weak CYP3A4 inhibitor and might slightly raise lapatinib exposure. Clinically important effects are not well documented, and estrogen-containing contraceptives are generally unsuitable in patients with hormone-sensitive breast cancer.
How serious is the interaction between Ethinyl estradiol-drospirenone and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; monitor for lapatinib adverse effects such as diarrhea, rash and QT changes. Use a non-hormonal contraceptive method during lapatinib therapy.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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