Drug interactions
Ethinyl estradiol-drospirenone + Leniolisib
Severity: Minor
Ethinyl estradiol-drospirenone and Leniolisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP and may modestly raise exposure to BCRP substrates. The effect on ethinyl estradiol is likely small and of limited clinical consequence.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Leniolisib belongs to Miscellaneous.
Why it happens
BCRP inhibition by leniolisib may reduce efflux of ethinyl estradiol.
What to do
No dose change is generally needed. Monitor for estrogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Leniolisib?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib inhibits BCRP and may modestly raise exposure to BCRP substrates. The effect on ethinyl estradiol is likely small and of limited clinical consequence.
How serious is the interaction between Ethinyl estradiol-drospirenone and Leniolisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for estrogenic adverse effects.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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