Drug interactions
Ethinyl estradiol-drospirenone + Mexiletine
Severity: Minor
Ethinyl estradiol-drospirenone and Mexiletine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP1A2 inhibitor, and mexiletine is partly cleared by CYP1A2 and CYP2D6. Mexiletine levels may rise modestly, which could increase dose-related neurological and cardiac adverse effects.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Mexiletine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP1A2-mediated mexiletine metabolism by ethinyl estradiol.
What to do
Monitor for tremor, dizziness, nausea or arrhythmia when starting the contraceptive, and check mexiletine levels or reduce the dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Mexiletine?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol is a weak CYP1A2 inhibitor, and mexiletine is partly cleared by CYP1A2 and CYP2D6. Mexiletine levels may rise modestly, which could increase dose-related neurological and cardiac adverse effects.
How serious is the interaction between Ethinyl estradiol-drospirenone and Mexiletine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, dizziness, nausea or arrhythmia when starting the contraceptive, and check mexiletine levels or reduce the dose if toxicity appears.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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