Drug interactions
Ethinyl estradiol-drospirenone + Mifepristone
Severity: Moderate
Ethinyl estradiol-drospirenone and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise ethinyl estradiol exposure. Its antiprogestogenic activity may also oppose the progestin component, which is relevant in chronic use such as Cushing's syndrome. Endometrial effects and reduced contraceptive reliability are possible.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by mifepristone plus progesterone receptor antagonism.
What to do
Use a non-hormonal contraceptive during long-term mifepristone therapy and monitor for estrogenic adverse effects or unexpected bleeding if co-administered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Mifepristone?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise ethinyl estradiol exposure. Its antiprogestogenic activity may also oppose the progestin component, which is relevant in chronic use such as Cushing's syndrome. Endometrial effects and reduced contraceptive reliability are possible.
How serious is the interaction between Ethinyl estradiol-drospirenone and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal contraceptive during long-term mifepristone therapy and monitor for estrogenic adverse effects or unexpected bleeding if co-administered.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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