Drug interactions
Ethinyl estradiol-drospirenone + Ramelteon
Severity: Minor
Ethinyl estradiol-drospirenone and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon is mainly metabolized by CYP1A2, which ethinyl estradiol inhibits weakly. Ramelteon exposure may increase, causing more daytime drowsiness or dizziness.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Ramelteon belongs to Central Nervous System.
Why it happens
Weak CYP1A2 inhibition by ethinyl estradiol reducing ramelteon clearance.
What to do
Monitor for excess sedation and reduce or stop ramelteon if residual drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Ramelteon?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon is mainly metabolized by CYP1A2, which ethinyl estradiol inhibits weakly. Ramelteon exposure may increase, causing more daytime drowsiness or dizziness.
How serious is the interaction between Ethinyl estradiol-drospirenone and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduce or stop ramelteon if residual drowsiness occurs.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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