Drug interactions
Ethinyl estradiol-drospirenone + Sulindac
Severity: Moderate
Ethinyl estradiol-drospirenone and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac, an NSAID, can reduce renal potassium excretion, and drospirenone has anti-mineralocorticoid effects. Hyperkalemia is possible with long-term use or renal impairment.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Sulindac belongs to Musculoskeletal.
Why it happens
Additive potassium retention from NSAID suppression of renal prostaglandins and drospirenone aldosterone antagonism.
What to do
Check serum potassium in the first cycle with long-term sulindac use; occasional use needs no monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Sulindac?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulindac, an NSAID, can reduce renal potassium excretion, and drospirenone has anti-mineralocorticoid effects. Hyperkalemia is possible with long-term use or renal impairment.
How serious is the interaction between Ethinyl estradiol-drospirenone and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in the first cycle with long-term sulindac use; occasional use needs no monitoring.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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