Drug interactions
Ethinyl estradiol-levonorgestrel + Perampanel
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses perampanel lowers levonorgestrel exposure, which could compromise contraceptive efficacy. The effect at lower doses is smaller.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Perampanel belongs to Central Nervous System.
Why it happens
Probable weak induction of CYP3A-mediated metabolism of levonorgestrel; mechanism not fully established.
What to do
Add a back-up non-hormonal contraceptive method, particularly when perampanel doses of 12 mg/day are used. Continue for a month after perampanel is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Perampanel?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At higher doses perampanel lowers levonorgestrel exposure, which could compromise contraceptive efficacy. The effect at lower doses is smaller.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a back-up non-hormonal contraceptive method, particularly when perampanel doses of 12 mg/day are used. Continue for a month after perampanel is stopped.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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