Drug interactions
Ethinylestradiol + Posaconazole
Severity: Minor
Ethinylestradiol and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can raise ethinylestradiol exposure by inhibiting CYP3A4. This may increase estrogenic adverse effects and, in theory, the thrombotic risk linked with higher estrogen exposure.
What this interaction means in plain words
Ethinylestradiol and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Posaconazole inhibits CYP3A4-mediated ethinylestradiol metabolism.
What to do
Monitor for estrogenic adverse effects such as nausea, breast tenderness and headache. Reassess the contraceptive or hormone regimen if effects are troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Ethinylestradiol with Posaconazole?
MediHelp rates the interaction as minor. Ethinylestradiol and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole can raise ethinylestradiol exposure by inhibiting CYP3A4. This may increase estrogenic adverse effects and, in theory, the thrombotic risk linked with higher estrogen exposure.
How serious is the interaction between Ethinylestradiol and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects such as nausea, breast tenderness and headache. Reassess the contraceptive or hormone regimen if effects are troublesome.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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