Drug interactions
Ethinylestradiol + Teriflunomide
Severity: Moderate
Ethinylestradiol and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide can raise systemic exposure to ethinylestradiol and levonorgestrel-containing oral contraceptives. Higher hormone exposure may increase estrogen-related adverse effects, although contraceptive efficacy is not reduced.
What this interaction means in plain words
Ethinylestradiol and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Teriflunomide appears to increase ethinylestradiol exposure through an incompletely understood mechanism, possibly involving BCRP or CYP inhibition.
What to do
Select oral contraceptive doses with the lowest effective ethinylestradiol content, and monitor for estrogenic adverse effects such as nausea, breast tenderness and hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Frequently asked questions
Can I take Ethinylestradiol with Teriflunomide?
MediHelp rates the interaction as moderate. Ethinylestradiol and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriflunomide can raise systemic exposure to ethinylestradiol and levonorgestrel-containing oral contraceptives. Higher hormone exposure may increase estrogen-related adverse effects, although contraceptive efficacy is not reduced.
How serious is the interaction between Ethinylestradiol and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Select oral contraceptive doses with the lowest effective ethinylestradiol content, and monitor for estrogenic adverse effects such as nausea, breast tenderness and hypertension.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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