Drug interactions
Ethinylestradiol + Tigecycline
Severity: Minor
Ethinylestradiol and Tigecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been proposed to reduce contraceptive estrogen levels by disrupting gut flora, but for most antibiotics well-controlled data show no meaningful loss of contraceptive efficacy. Tigecycline has also been labeled with a caution about reduced effectiveness of oral contraceptives.
What this interaction means in plain words
Ethinylestradiol and Tigecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduced enterohepatic recycling of ethinylestradiol via altered gut flora; not firmly established.
What to do
Advise patients using oral contraceptives of the possible reduced reliability and consider a backup barrier method during tigecycline therapy. Reinforce adherence and manage vomiting or diarrhea as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinylestradiol and Tigecycline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tigecycline
Frequently asked questions
Can I take Ethinylestradiol with Tigecycline?
MediHelp rates the interaction as minor. Ethinylestradiol and Tigecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been proposed to reduce contraceptive estrogen levels by disrupting gut flora, but for most antibiotics well-controlled data show no meaningful loss of contraceptive efficacy. Tigecycline has also been labeled with a caution about reduced effectiveness of oral contraceptives.
How serious is the interaction between Ethinylestradiol and Tigecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients using oral contraceptives of the possible reduced reliability and consider a backup barrier method during tigecycline therapy. Reinforce adherence and manage vomiting or diarrhea as usual.
What other medicines interact with Tigecycline?
MediHelp also lists interactions of Tigecycline with, for example, Typhoid vaccine live, Bcg vaccine live, Cholera vaccine. The full list is on the Tigecycline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
