Drug interactions
Ethosuximide + Teclistamab
Severity: Moderate
Ethosuximide and Teclistamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teclistamab induces cytokine release that can temporarily suppress CYP enzyme activity, potentially raising ethosuximide levels. The effect is most likely after step-up doses and during cytokine release syndrome.
What this interaction means in plain words
Ethosuximide and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethosuximide belongs to Central Nervous System; Teclistamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP enzymes reducing ethosuximide clearance.
What to do
Monitor for ethosuximide toxicity after teclistamab initiation and during cytokine release syndrome, reducing the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
Frequently asked questions
Can I take Ethosuximide with Teclistamab?
MediHelp rates the interaction as moderate. Ethosuximide and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teclistamab induces cytokine release that can temporarily suppress CYP enzyme activity, potentially raising ethosuximide levels. The effect is most likely after step-up doses and during cytokine release syndrome.
How serious is the interaction between Ethosuximide and Teclistamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ethosuximide toxicity after teclistamab initiation and during cytokine release syndrome, reducing the dose if needed.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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