Drug interactions
Carbamazepine + Teclistamab
Severity: Moderate
Carbamazepine and Teclistamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release after teclistamab can transiently suppress CYP enzymes and raise carbamazepine concentrations, risking toxicity.
What this interaction means in plain words
Carbamazepine and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Teclistamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 reduces carbamazepine metabolism.
What to do
Monitor for carbamazepine toxicity and check levels during step-up dosing and CRS, adjusting the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
- Ethosuximide + Teclistamab Moderate
Frequently asked questions
Can I take Carbamazepine with Teclistamab?
MediHelp rates the interaction as moderate. Carbamazepine and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release after teclistamab can transiently suppress CYP enzymes and raise carbamazepine concentrations, risking toxicity.
How serious is the interaction between Carbamazepine and Teclistamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for carbamazepine toxicity and check levels during step-up dosing and CRS, adjusting the dose as needed.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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